Interleukin-4 (IL-4) Induces Phosphatidylinositol 3-Kinase (p85) Dephosphorylation
نویسندگان
چکیده
منابع مشابه
Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase.
We have previously demonstrated that interleukin-4 (IL-4) induces tyrosine phosphorylation of a protein closely related or identical to the c-fes proto-oncogene product (FES) and association of this protein with the IL-4 receptor alpha chain (IL-4R alpha). IL-4 is known to induce association of phosphatidylinositol-3 (PI3) kinase with the IL-4R alpha. Since FES contains the consensus motifs for...
متن کاملCharacterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85
Phosphatidylinositol 3-kinase is a key step in the metabolic actions of insulin. Two amino acid substitutions have been identified in the gene for the regulatory subunit of human p85 , Met-326Ile, and Asn-330Asp, and the former has been associated with alterations in glucose insulin homeostasis. When the four human p85 proteins were expressed in yeast, a 27% decrease occurred in the level of pr...
متن کاملRegulation of the p85/p110a Phosphatidylinositol 3*-Kinase
Our previous studies on the p85/p110a phosphatidylinositol 3-kinase showed that the p85 regulatory subunit inhibits the p110a catalytic subunit, and that phosphopeptide activation of p85/p110a dimers reflects a disinhibition of p110a (Yu, J., Zhang, Y., McIlroy, J., Rordorf-Nikolic, T., Orr, G. A., and Backer, J. M. (1998) Mol. Cell. Biol. 18, 1379–1387). We now define the domains of p85 requir...
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Phosphatidylinositol-4-kinase-IIIbeta (PI4KIIIbeta) is activated at the Golgi compartment by PKD-mediated phosphorylation. Subsequent mechanisms responsible for continuous PtdIns(4)P production at Golgi membranes and potential interaction partners of activated PI4KIIIbeta are unknown. Here we identify phosphoserine/-threonine binding 14-3-3 proteins as novel regulators of PI4KIIIbeta activity d...
متن کاملDecreased mucosal interleukin-4 (IL-4) production in gut inflammation.
AIMS To determine the prevalence of cells secreting interleukin-4 (IL-4) in the gut mucosa of children with chronic inflammatory bowel disease. METHODS Mononuclear cells were isolated from intestinal biopsy specimens from control children (n = 10) and children with active inflammatory bowel disease (Crohn's disease n = 15, ulcerative colitis n = 9, indeterminate colitis n = 3). Spontaneous IL...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.12.7927